Tourette

Tourette syndrome Classification Characteristics Causes Diagnosis Screening Management Prognosis Epidemiology History and research directions

History and research directions

A French doctor, Jean Marc Gaspard Itard, reported the first case of Tourette syndrome in 1825,[77] describing Marquise de Dampierre, an important woman of nobility in her time.[12] Jean-Martin Charcot, an influential French physician, assigned his resident Georges Albert Édouard Brutus Gilles de la Tourette, a French physician and neurologist, to study patients at the Salpêtrière Hospital, with the goal of defining an illness distinct from hysteria and from chorea.[25]

In 1885, Gilles de la Tourette published an account of nine patients, Study of a Nervous Affliction, concluding that a new clinical category should be defined.[78] The eponym was later bestowed by Charcot after and on behalf of Gilles de la Tourette.[25][79]

Little progress was made over the next century in explaining or treating tics, and a psychogenic view prevailed well into the 20th century.[25] The possibility that movement disorders, including Tourette syndrome, might have an organic origin was raised when an encephalitis epidemic from 1918–1926 led to a subsequent epidemic of tic disorders.[80]

During the 1960s and 1970s, as the beneficial effects of haloperidol (Haldol) on tics became known, the psychoanalytic approach to Tourette syndrome was questioned.[81] The turning point came in 1965, when Arthur K. Shapiro—described as "the father of modern tic disorder research"[82]—treated a Tourette’s patient with haloperidol, and published a paper criticizing the psychoanalytic approach.[80]

Since the 1990s, a more neutral view of Tourette's has emerged, in which biological vulnerability and adverse environmental events are seen to interact.[6][25] In 2000, the American Psychiatric Association published the DSM-IV-TR, revising the text of DSM-IV to no longer require that symptoms of tic disorders cause distress or impair functioning.[83]

Findings since 1999 have advanced TS science in the areas of genetics, neuroimaging, neurophysiology, and neuropathology. Questions remain regarding how best to classify Tourette syndrome, and how closely Tourette's is related to other movement disorders or psychiatric disorders. Good epidemiologic data is still lacking, and available treatments are not risk free and not always well tolerated.[84] High-profile media coverage focuses on treatments that do not have established safety or efficacy, such as deep brain stimulation, and alternative therapies involving unstudied efficacy and side effects are pursued by many parents